Job Description

Title: Postdoctoral Associate, Human Microvascular Models and Extracellular Matrix Biology
Location: Onsite, Pittsburgh, PA 15213
Type: Direct-Hire/Permanent
Hours: Standard business hours
Start: May
Overview: We are loo king for a highly motivated Postdoctoral Associate to join a lab focused on discovering novel therapeutics. This interdisciplinary program develops advanced in vitro models of hematopoietic and immune system function such as conducting research at the intersection of microphysiological systems (Organs-on-Chips) and immunology. The role emphasizes the use of microphysiological systems to model human microvascular structure and function within physiologically relevant three-dimensional microenvironments, with a particular focus on endothelial–stromal interactions, matrix remodeling, and tissue-level responses under dynamic conditions.

• Design and execute experimental studies using advanced in vitro microvascular and tissue-engineered systems, including endothelial and stromal cell components
• Establish and maintain multicellular cultures within three-dimensional microenvironments to investigate vascular function and ECM remodeling
• Perform and optimize assays to evaluate vascular integrity, permeability, inflammatory signaling, and matrix-related processes
• Contribute to development and refinement of experimental workflows, including matrix composition, cell seeding strategies, and system reproducibility
• Collaborate with multidisciplinary teams to integrate microvascular data with complementary model systems and analytical platforms
• Maintain accurate and detailed documentation of experimental procedures and results
• Analyze and interpret data, and contribute to preparation of manuscripts, reports, and grant applications
• Mentor trainees and assist in training of laboratory personnel as needed

Requirements:

• Ph.D. in Biomedical Engineering, Vascular Biology, Cell Biology, or a related field
• Experience with primary human endothelial and stromal cell culture and/or multicellular in vitro systems
• Background in extracellular matrix biology, tissue remodeling, or microenvironmental regulation
• Strong experimental design, analytical, and problem-solving skills
• Ability to work independently and collaboratively in a multidisciplinary research environment
• Strong written and verbal communication skills

Preferred:

• Experience with three-dimensional culture systems or Organs-on-Chips
• Familiarity with assays for vascular permeability, matrix remodeling, or mechanobiology
• Experience with imaging-based, biophysical, or quantitative molecular analyses
• Experience working in interdisciplinary teams integrating biology and engineering

#M3
Ref: #558-Scientific

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System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

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